Journal article
A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies
JM Wasielewska, JCS Chaves, RL Johnston, LA Milton, D Hernández, L Chen, J Song, W Lee, G Leinenga, RM Nisbet, A Pébay, J Götz, AR White, LE Oikari
Theranostics | Published : 2022
DOI: 10.7150/thno.72685
Open access
Abstract
Rationale: The blood-brain barrier (BBB) is a major impediment to therapeutic intracranial drug delivery for the treatment of neurodegenerative diseases, including Alzheimer’s disease (AD). Focused ultrasound applied together with microbubbles (FUS+MB) is a novel technique to transiently open the BBB and increase drug delivery. Evidence suggests that FUS+MB is safe, however, the effects of FUS+MB on human BBB cells, especially in the context of AD, remain sparsely investigated. In addition, there currently are no cell platforms to test for FUS+MB-mediated drug delivery. Methods: Here we generated BBB cells (induced brain endothelial-like cells (iBECs) and astrocytes (iAstrocytes)) from apoli..
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Awarded by University of Queensland
Funding Acknowledgements
This work was supported by: National Health and Medical Research Council (NHMRC) Senior Research Fellowship (1154389) (AP); National Health and Medical Research Council (NHMRC) Senior Research Fellowship (1118452) (ARW). DH was supported by Yulgilbar Alzheimer's Research Program grant. JMW is a recipient of The University of Queensland PhD scholarship.